Thread-embedding acupuncture for lumbar herniated intervertebral disc: Protocol for a systematic review and meta-analysis

Lumbar herniated intervertebral disc (LHIVD) is a frequent disease among patients attending Korean medicine hospitals, and it is associated with considerable medical expenses for the patients.

Although several recent randomized clinical trials (RCTs) have reported that thread-embedding acupuncture (TEA) has a more favorable therapeutic effect on LHIVD than other types of acupuncture or other treatments, the evidence remains limited because these trials used poor assessment methods and had a high risk of bias.

This study aims to evaluate the evidence for the effectiveness and safety of TEA for LHIVD. In this article, we describe our methods and plan for a systematic review.

MF-438

407862 10.0mg
EUR 450

MF-438

B1178-25 each
EUR 810

MF-438

B1178-5 each
EUR 248.4

MF498

C3928-1 1 mg
EUR 65
Description: EP4 receptor antagonist

MF498

C3928-10 10 mg
EUR 513
Description: EP4 receptor antagonist

MF498

C3928-25 25 mg
EUR 1122
Description: EP4 receptor antagonist

MF498

C3928-5 5 mg
EUR 289
Description: EP4 receptor antagonist

MF-766

555439 5.0mg
EUR 420

MF-094

HY-112438 50mg
EUR 3159.6

MF498

HY-10794 10mg
EUR 753.6

MF-766

T9622-10mg 10mg Ask for price
Description: MF-766

MF-766

T9622-1g 1g Ask for price
Description: MF-766

MF-766

T9622-1mg 1mg Ask for price
Description: MF-766

MF-766

T9622-50mg 50mg Ask for price
Description: MF-766

MF-766

T9622-5mg 5mg Ask for price
Description: MF-766

MF-094

T12024-10mg 10mg Ask for price
Description: MF-094

MF-094

T12024-1g 1g Ask for price
Description: MF-094

MF-094

T12024-1mg 1mg Ask for price
Description: MF-094

MF-094

T12024-50mg 50mg Ask for price
Description: MF-094

MF-094

T12024-5mg 5mg Ask for price
Description: MF-094

MF-438

T16068-10mg 10mg Ask for price
Description: MF-438

MF-438

T16068-1g 1g Ask for price
Description: MF-438

MF-438

T16068-1mg 1mg Ask for price
Description: MF-438

MF-438

T16068-50mg 50mg Ask for price
Description: MF-438

MF-438

T16068-5mg 5mg Ask for price
Description: MF-438

MF498

T16069-10mg 10mg Ask for price
Description: MF498

MF498

T16069-1g 1g Ask for price
Description: MF498

MF498

T16069-1mg 1mg Ask for price
Description: MF498

MF498

T16069-50mg 50mg Ask for price
Description: MF498

MF498

T16069-5mg 5mg Ask for price
Description: MF498

MF-438

abx283049-100g 100 µg Ask for price

MF-438

abx283049-20g 20 µg
EUR 131.25

MF-438

abx283049-50g 50 µg
EUR 350

HIV type 1 Glycoprotein 120 (aa 29 - 503)(MF535.W0M.ENV.D11) [His]

DAG2063 100 µg
EUR 1095.6

Monoclonal FGFR1 Antibody (N-Terminus, clone M2F12), Clone: M2F12

AMM02100G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human FGFR1 (N-Terminus, clone M2F12). The antibodies are raised in Mouse and are from clone M2F12. This antibody is applicable in WB and IHC-P, IP

Anti-SOCS6 (M2-F12)

YF-MA16765 100 ug
EUR 435.6
Description: Mouse monoclonal to SOCS6

OZ Biosciences Magnetofection Starting Kit (PN30100+CM20100+MF10096) - 1KIT

KC30296 1KIT
EUR 845.1

Dreschel Head Mf48/03/500 - EACH

QMF48/03/500 EACH
EUR 108

Dreshel Head+Sin Mf48/13/500 - EACH

QMF48/13/500 EACH
EUR 102.6

Dreschl Head Sint Mf48/23/ 215mm - EACH

QMF48/23/500 EACH
EUR 106.65

Nalgene CA MF75 500ml 0.2um Filter Unit

FIL8054 PK12
EUR 309.12

Nalgene CA MF75 500ml 0.45um Filter Unit

FIL8056 PK12
EUR 309.12

Nalgene CA MF75 150ml 0.2um Filter Unit - PK12

FIL8038 PK12
EUR 205.2

Nalgene CA MF75 250ml 0.2um Filter Unit - PK12

FIL8042 PK12
EUR 225.45

Nalgene CA MF75 500ml 0.2um Filter Unit - PK12

FIL8046 PK12
EUR 363.15

MF-63

522527 5.0mg
EUR 240

MF63

A3600-10 10 mg
EUR 238
Description: MPGES-1 inhibitor

MF63

A3600-100 100mg
EUR 1588
Description: MPGES-1 inhibitor

MF63

A3600-25 25 mg
EUR 567.6
Description: IC50: 0.9 and 1.3 nM for pig mPGES-1 and human mPGES-1MF63 is a potent, selective and orally active mPGES-1 inhibitor. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E2 synthase in the cyclooxygenase pathway.

MF63

A3600-5 5 mg
EUR 146
Description: MPGES-1 inhibitor

MF63

A3600-50 50mg
EUR 953
Description: MPGES-1 inhibitor

MF63

HY-13283 5mg
EUR 198

MF63

T16070-10mg 10mg Ask for price
Description: MF63

MF63

T16070-1g 1g Ask for price
Description: MF63

MF63

T16070-1mg 1mg Ask for price
Description: MF63

MF63

T16070-50mg 50mg Ask for price
Description: MF63

MF63

T16070-5mg 5mg Ask for price
Description: MF63

CD5 mouse monoclonal antibody, clone MF7-14.5, PE

SM1062R 100 Tests Ask for price

CD5 mouse monoclonal antibody, clone MF7-14.5, PE

SM1062RT 25 Tests Ask for price

Nalgene CA MF75 115ml 0.45um Filter Unit - PK12

FIL8036 PK12
EUR 163.35

Nalgene CA MF75 150ml 0.45um Filter Unit - PK12

FIL8040 PK12
EUR 205.2

Nalgene CA MF75 250ml 0.45um Filter Unit - PK12

FIL8044 PK12
EUR 225.45

Nalgene CA MF75 500ml 0.45um Filter Unit - PK12

FIL8048 PK12
EUR 363.15

Nalgene Nylon MF75 500ml 0.2um Filter Unit

FIL8126 PK12
EUR 338.88

CD5 mouse monoclonal antibody, clone MF7-14.5, FITC

SM1062F 100 µg Ask for price

Nalgene Nylon MF75 150ml 0.2um Filter Unit - PK12

FIL8108 PK12
EUR 221.4

Nalgene Nylon MF75 250ml 0.2um Filter Unit - PK12

FIL8112 PK12
EUR 233.55

Nalgene Nylon MF75 500ml 0.2um Filter Unit - PK12

FIL8116 PK12
EUR 379.35

Nalgene Nylon MF75 150ml 0.45um Filter Unit - PK12

FIL8110 PK12
EUR 221.4

Nalgene Nylon MF75 250ml 0.45um Filter Unit - PK12

FIL8114 PK12
EUR 233.55

Nalgene Nylon MF75 500ml 0.45um Filter Unit - PK12

FIL8118 PK12
EUR 379.35

CD5 mouse monoclonal antibody, clone MF7-14.5, Purified

SM1062P 2 ml Ask for price

Monoclonal CSTB / Cystatin B / Stefin B Antibody (clone M2F1), Clone: M2F1

AMM02083G 0.05mg
EUR 633.6
Description: A Monoclonal antibody against Human CSTB / Cystatin B / Stefin B (clone M2F1). The antibodies are raised in Mouse and are from clone M2F1. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal SOCS6 Antibody (monoclonal) (M01), Clone: M2-F12

AMM07944G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human SOCS6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone M2-F12. This antibody is applicable in WB, E

Anti-SET (M1-F5)

YF-MA10830 100 ug
EUR 435.6
Description: Mouse monoclonal to SET

Anti-BMP7 (M1-F8)

YF-MA10098 100 ug
EUR 435.6
Description: Mouse monoclonal to BMP7

Anti-Stefin B (M2-F1)

YF-MA10203 100 ug
EUR 435.6
Description: Mouse monoclonal to Stefin B

Nalgene CA MF75 1L 0.2um Filter Unit

FIL8058 PK12
EUR 387.84

Drying Tube Angled Mf23/1 14/23 - EACH

QMF23/1 EACH
EUR 41.85

Drying Tube Angled Mf23/2 19/26 - EACH

QMF23/2 EACH
EUR 47.25

Drying Tube Angled Mf23/3 24/29 - EACH

QMF23/3 EACH
EUR 55.35

Nalgene MF75 Receiver 1L - PK12

FIL8026 PK12
EUR 207.9

Nalgene CA MF75 1L 0.45um Filter Unit

FIL8060 PK12
EUR 387.84

Nalgene CA MF75 1L 0.2um Filter Unit - PK12

FIL8050 PK12
EUR 465.75

Nalgene MF75 Receiver 500ml - PK12

FIL8024 PK12
EUR 144.45

Nalgene CA MF75 1L 0.45um Filter Unit - PK12

FIL8052 PK12
EUR 465.75

Nalgene Nylon MF75 1L 0.2um Filter Unit

FIL8128 PK12
EUR 391.68

Nalgene MF75 Receiver 150ml - PK24

FIL8020 PK24
EUR 183.6

Nalgene MF75 Receiver 250ml - PK24

FIL8022 PK24
EUR 207.9

IKA Impact Grinding Head MF10 2 - EACH

MIL2114 EACH
EUR 5244.75

IKA Cutting Grinding Head MF10 1 - EACH

MIL2112 EACH
EUR 5872.5

Nalgene Nylon MF75 1L 0.2um Filter Unit - PK12

FIL8120 PK12
EUR 473.85

Nalgene MF75 PES 90mm x 0.2um x 1L Filter Unit - PK12

FIL8416 PK12
EUR 427.95

Anti-Foxp3 Antibody [MF23], PE-25ug

QAB27-PE-25ug 25ug
EUR 240

Nalgene Nylon MF75 1L 0.45um Filter Unit - PK12

FIL8122 PK12
EUR 473.85

Nalgene PES MF75 90mm x 0.2um x 1L Bottle Top Filter

FIL8195 PK12
EUR 268.8

Nalgene MF75 PES 90mm x 0.45um x 1L Filter Unit - PK12

FIL8418 PK12
EUR 453.6

Anti-Foxp3 Antibody [MF23], APC-25ug

QAB27-APC-25ug 25ug
EUR 240

Anti-Foxp3 Antibody [MF23], PE-100ug

QAB27-PE-100ug 100ug
EUR 442.8

Dreschel Head Adjustable Mf27/3/ - EACH

QMF27/3/13 EACH
EUR 83.7

Nalgene CA MF75 50mm x 0.2um x 150ml Bottle Top Filter

FIL8150 PK12
EUR 109.44

Nalgene CA MF75 50mm x 0.2um x 500ml Bottle Top Filter

FIL8154 PK12
EUR 154.56

Nalgene CA MF75 50mm x 0.2um x 1L Bottle Top Filter - PK12

FIL8158 PK12
EUR 349.65

Nalgene MF75 PES 50mm x 0.1um x 150ml filter unit - PK12

FIL8397 PK12
EUR 187.65

Nalgene MF75 PES 50mm x 0.2um x 150ml Filter Unit - PK12

FIL8400 PK12
EUR 184.95

Nalgene MF75 PES 75mm x 2um x 250ml Filter Unit - PK12

FIL8404 PK12
EUR 202.5

Nalgene MF75 PES 75mm x 0.2um x 500ml Filter Unit - PK12

FIL8408 PK12
EUR 336.15

Nalgene MF75 PES 90mm x 0.2um x 500ml Filter Unit - PK12

FIL8412 PK12
EUR 395.55

Anti-Foxp3 Antibody [MF23], APC-100ug

QAB27-APC-100ug 100ug
EUR 442.8

Nalgene CA MF75 50mm x 0.45um x 1L Bottle Top Filter - PK12

FIL8148 PK12
EUR 349.65

Nalgene CA MF75 50mm x 0.45um x 150ml Bottle Top Filter

FIL8152 PK12
EUR 109.44

Nalgene CA MF75 50mm x 0.45um x 500ml Bottle Top Filter

FIL8156 PK12
EUR 154.56

Nalgene PES MF75 90mm x 0.2um x 1L Bottle Top Filter - PK12

FIL8181 PK12
EUR 384.75

Nalgene PES MF75 75mm x 0.2um x 500ml Bottle Top Filter

FIL8184 PK12
EUR 137.28

Nalgene MF75 PES 50mm x 0.45um x 150ml Filter Unit - PK12

FIL8402 PK12
EUR 195.75

Nalgene MF75 PES 75mm x 0.45um x 250ml Filter Unit - PK12

FIL8406 PK12
EUR 225.45

Nalgene MF75 PES 75mm x 0.45um x 500ml Filter Unit - PK12

FIL8410 PK12
EUR 361.8

Nalgene MF75 PES 90mm x 0.45um x 500ml Filter Unit - PK12

FIL8414 PK12
EUR 429.3

Nalgene CA MF75 50mm x 0.2um x 150ml Bottle Top Filter - PK12

FIL8140 PK12
EUR 153.9

Nalgene CA MF75 50mm x 0.2um x 500ml Bottle Top Filter - PK12

FIL8144 PK12
EUR 217.35

Nalgene PES MF75 75mm x 0.45um x 500ml Bottle Top Filter

FIL8186 PK12
EUR 148.8

D-Tryptophan (MF-10), RNA Aptamer, unlabeled

AR-226-U Custom Ask for price

Nalgene CA MF75 50mm x 0.45um x 150ml Bottle Top Filter - PK12

FIL8142 PK12
EUR 153.9

Nalgene CA MF75 50mm x 0.45um x 500ml Bottle Top Filter - PK12

FIL8146 PK12
EUR 217.35

Nalgene PES MF75 75mm x 0.2um x 500ml Bottle Top Filter - PK12

FIL8180 PK12
EUR 199.8

Nalgene PES MF75 50mm x 0.2um x 150ml Bottle Top Filter - PK12

FIL8188 PK12
EUR 145.8

Nalgene PES MF75 75mm x 0.2um x 150ml Bottle Top Filter - PK12

FIL8192 PK12
EUR 140.4

EMA (MUC1) mouse monoclonal antibody, clone M2F1

4M40-M2F1 1 mg Ask for price

Foxp3 rat monoclonal antibody, clone MF-14, FITC

AM26534FC-N 50 Tests Ask for price

Nalgene PES MF75 75mm x 0.45um x 500ml Bottle Top Filter - PK12

FIL8182 PK12
EUR 216

Nalgene PES MF75 50mm x 0.45um x 150ml Bottle Top Filter - PK12

FIL8190 PK12
EUR 152.55

Nalgene PES MF75 75mm x 0.45um x 150ml Bottle Top Filter - PK12

FIL8194 PK12
EUR 152.55

Anti-Drebrin Monoclonal Antibody (M2F6)

M05530-1 100ug
EUR 504
Description: Mouse Monoclonal Drebrin Antibody (M2F6). Validated in IP, IF, WB and tested in Mouse, Rat.

Anti-Human Ferritin Antibody | MF-80A-100

MF-80A-100 1.0 mg
EUR 334
Description:

Anti-Human Ferritin Antibody ; MF-80A-100 ; Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Anti-Human Ferritin Antibody | MF-80A-101

MF-80A-101 1.0 mg
EUR 334
Description:

Anti-Human Ferritin Antibody ; MF-80A-101 ; Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Anti-Human Ferritin Antibody | MF-80A-102

MF-80A-102 1.0 mg
EUR 334
Description:

Anti-Human Ferritin Antibody ; MF-80A-102 ; Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Mouse Monoclonal S100A8/A9 Antibody (48M5F4)

TA337126 100 µg Ask for price

Foxp3 rat monoclonal antibody, clone MF-14, Biotin

AM26534BT-S 100 µl Ask for price

Foxp3 rat monoclonal antibody, clone MF-14, Azide Free

AM26534AF-N 100 µg Ask for price

Monoclonal SET Antibody (monoclonal) (M01), Clone: M1-F5

AMM04085G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human SET (monoclonal) (M01). The antibodies are raised in mouse and are from clone M1-F5. This antibody is applicable in WB and IF, E

Monoclonal CSTB Antibody (monoclonal) (M02), Clone: M2-F1

AMM03427G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CSTB (monoclonal) (M02). The antibodies are raised in mouse and are from clone M2-F1. This antibody is applicable in WB, IHC and IF

Stefin B (CSTB) mouse monoclonal antibody, clone M2-F1, Purified

AM31774PU-N 50 µg Ask for price

Recombinant Caenorhabditis Elegans M01F1.3 Protein (aa 1-354)

VAng-Ly3530-inquire inquire Ask for price
Description: Caenorhabditis Elegans lipoyl synthase, mitochondrial (M01F1.3), partial, recombination protein.

Recombinant Caenorhabditis Elegans M01F1.6 Protein (aa 1-158)

VAng-Ly3531-inquire inquire Ask for price
Description: Caenorhabditis Elegans probable 39S ribosomal protein L35, mitochondrial (M01F1.6), partial, recombination protein.

mF3

pro-2316 2µg
EUR 60
Description: Recombinant Mouse Coagulation Factor III

MF2L2 rabbit pAb

E28PN5095 100μl
EUR 255
Description: Available in various conjugation types.

TGFalpha(MF9), 0.2mg/mL

BNUB0644-100 100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

TGFalpha(MF9), 0.2mg/mL

BNUB0644-500 500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

TGFalpha(MF9), 1mg/mL

BNUM0644-50 50uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MF2L2 rabbit pAb

E44H13979 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

anti-JNK1(M11) (2F11)

LF-MA10190 100 ug
EUR 435.6
Description: Mouse monoclonal to JNK1(M11)

M13-FITC, Antibody

GWB-EE5E55 0.25 ml Ask for price

MF4 ORF Vector (Human) (pORF)

ORF023508 1.0 ug DNA Ask for price

MF4 3'UTR GFP Stable Cell Line

TU063284 1.0 ml
EUR 2799.6

Kinesis CV Inlet; 1/4-28M to 1/4-28F; 3psi

CHR3277 EACH
EUR 146.67

MFAP3L(MF3L-4)Antibody

E551010-4-PU 100ug
EUR 295
Description: Available in various conjugation types.

TGFalpha(MF9) Antibody

BNC810644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF680R conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC810644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF680R conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC800644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF680 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC800644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF680 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC430644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF543 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC430644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF543 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC050644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF405M conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC050644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF405M conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC550644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF555 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC550644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF555 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC700644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF770 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC700644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF770 conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC610644-100 100uL
EUR 238.8
Description: Primary antibody against TGFalpha(MF9), CF660R conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNC610644-500 500uL
EUR 652.8
Description: Primary antibody against TGFalpha(MF9), CF660R conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNCP0644-250 250uL
EUR 459.6
Description: Primary antibody against TGFalpha(MF9), PerCP conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNCR0644-250 250uL
EUR 459.6
Description: Primary antibody against TGFalpha(MF9), RPE conjugate, Concentration: 0.1mg/mL

TGFalpha(MF9) Antibody

BNCA0644-250 250uL
EUR 459.6
Description: Primary antibody against TGFalpha(MF9), APC conjugate, Concentration: 0.1mg/mL

We will conduct an electronic search of the following databases from their inception to May 2018: MEDLINE; EMBASE; COCHRANE; China National Knowledge Infrastructure (CNKI) (a Chinese database); CiNii and J-STAGE (Japanese databases); and KoreaMed, Korean Medical Database (KMbase), Korean Studies Information Service System (KISS),

National Digital Science Library (NDSL), Korea Institute of Science and Technology Information (KISTI), Oriental Medicine Advanced Searching Integrated System (OASIS). RCTs investigating any type of TEA will be included. The risk of bias in each study will be evaluated using the Cochrane risk of bias tool.

Risk ratios or mean differences with 95% confidence intervals will be used to show the effects of TEA if it will be possible to conduct a meta-analysis. Sensitivity analyses will also be conducted in this study.

Ethical approval is not necessary as this paper does not involve patient data. The review will be published in a peer-reviewed journal or presented in a conference.PROSPERO CRD42019133060.