Thread-embedding acupuncture for lumbar herniated intervertebral disc: Protocol for a systematic review and meta-analysis

Lumbar herniated intervertebral disc (LHIVD) is a frequent disease among patients attending Korean medicine hospitals, and it is associated with considerable medical expenses for the patients.

Although several recent randomized clinical trials (RCTs) have reported that thread-embedding acupuncture (TEA) has a more favorable therapeutic effect on LHIVD than other types of acupuncture or other treatments, the evidence remains limited because these trials used poor assessment methods and had a high risk of bias.

This study aims to evaluate the evidence for the effectiveness and safety of TEA for LHIVD. In this article, we describe our methods and plan for a systematic review.

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HIV type 1 Glycoprotein 120 (aa 29 - 503)(MF535.W0M.ENV.D11) [His]
DAG2063 100 µg
EUR 756
Description: Recombinant

MF-766
555439 5.0mg
EUR 420

MF498
532179 5.0mg
EUR 400

MF-094
593145 5.0mg
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MF-438
407862 10.0mg
EUR 450

MF-095
471072 5.0mg
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MF-438
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MF-438
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MF-438
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MF498
C3928-1 1 mg
EUR 64.8
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MF498
C3928-10 10 mg
EUR 512.8
Description: GPCR/G protein|Prostaglandin Receptor

MF498
C3928-25 25 mg
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Description: GPCR/G protein|Prostaglandin Receptor

MF498
C3928-5 5 mg
EUR 288.8
Description: GPCR/G protein|Prostaglandin Receptor

MF498
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HY-112438 50mg
EUR 627.72
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HY-115487 10 mg
EUR 1190.49
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MF498
HY-10794 10mg
EUR 298.71
Description: MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a Ki value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis[1][2].

MF-438
HY-15822 1 mg
EUR 1369.07
Description: MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].

MF498
MBS3841156-10mg 10mg
EUR 380

MF498
MBS3841156-2mg 2mg
EUR 170

MF498
MBS3841156-5mg 5mg
EUR 245

MF498
MBS3841156-5x10mg 5x10mg
EUR 1710

MF-438
MBS3845398-10mg 10mg
EUR 1905

MF-438
MBS3845398-1mg 1mg
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MF-438
MBS3845398-5mg 5mg
EUR 1165

MF-438
MBS3845398-5x10mg 5x10mg
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MF-094
MBS3843717-100mg 100mg
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MF-094
MBS3843717-10mg 10mg
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MF-094
MBS3843717-50mg 50mg
EUR 2450

MF-094
MBS3843717-5mg 5mg
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MF-094
MBS3843717-5x100mg 5x100mg
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MF-438
MBS5755182-10mg 10mg
EUR 405

MF-438
MBS5755182-1mg 1mg
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MF-438
MBS5755182-25mg 25mg
EUR 675

MF-438
MBS5755182-2mg 2mg
EUR 240

MF-438
MBS5755182-5mg 5mg
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MF498
MBS5755183-25mg 25mg
EUR 980

MF498
MBS5755183-5x25mg 5x25mg
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MF-094
MBS5753479-10mg 10mg
EUR 280

MF-094
MBS5753479-1mg 1mg
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MF-094
MBS5753479-25mg 25mg
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MF-094
MBS5753479-50mg 50mg
EUR 695

MF-094
MBS5753479-5mg 5mg
EUR 200

MF-766
MBS5786467-10mg 10(mg
EUR 460

MF-766
MBS5786467-1mg 1(mg
EUR 220

MF-766
MBS5786467-5mg 5(mg
EUR 300

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Monoclonal FGFR1 Antibody (N-Terminus, clone M2F12), Clone: M2F12
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Anti-SOCS6 (M2-F12)
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OZ Biosciences Magnetofection Starting Kit (PN30100+CM20100+MF10096) - 1KIT
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MF63
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Description: IC50: 0.9 and 1.3 nM for pig mPGES-1 and human mPGES-1MF63 is a potent, selective and orally active mPGES-1 inhibitor. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E2 synthase in the cyclooxygenase pathway.

MF63
A3600-5 5 mg
EUR 145.6
Description: Neuroscience|mPEGS-1

MF63
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Description: Neuroscience|mPEGS-1

MF-63
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MF59
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Description: MF59 is a immunologic adjuvant. MF59 significantly influnces immunogenicity of influenza vaccines. MF59 reduces the viral load in the lungs of challenged mice[1].

MF63
HY-13283 5mg
EUR 714.3
Description: MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE2, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1[1].

MF63
MBS386807-10mg 10mg
EUR 175

MF63
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MF63
MBS386807-5mg 5mg
EUR 145

MF63
MBS386807-5x25mg 5x25mg
EUR 1160

MF63
MBS3606431-50mg 50mg
EUR 655

MF63
MBS3606431-5x50mg 5x50mg
EUR 2620

MF63
MBS5755184-100mg 100mg
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Monoclonal CSTB / Cystatin B / Stefin B Antibody (clone M2F1), Clone: M2F1
AMM02083G 0.05mg
EUR 633.6
Description: A Monoclonal antibody against Human CSTB / Cystatin B / Stefin B (clone M2F1). The antibodies are raised in Mouse and are from clone M2F1. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal SOCS6 Antibody (monoclonal) (M01), Clone: M2-F12
AMM07944G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human SOCS6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone M2-F12. This antibody is applicable in WB, E

Anti-SET (M1-F5)
YF-MA10830 100 ug
EUR 435.6
Description: Mouse monoclonal to SET

Anti-BMP7 (M1-F8)
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EUR 435.6
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Description: Recombinant Caenorhabditis elegans M01F1.3 protein

Anti-Stefin B (M2-F1)
YF-MA10203 100 ug
EUR 435.6
Description: Mouse monoclonal to Stefin B

PE Anti-Mouse Foxp3 (MF23)
MBS4165513-01mg 0.1mg
EUR 470

PE Anti-Mouse Foxp3 (MF23)
MBS4165513-5x01mg 5x0.1mg
EUR 1850

APC Anti-Mouse Foxp3 (MF23)
MBS4165284-01mg 0.1mg
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APC Anti-Mouse Foxp3 (MF23)
MBS4165284-5x01mg 5x0.1mg
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Nalgene CA MF75 1L 0.2um Filter Unit
FIL8058 PK12
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Drying Tube Angled Mf23/1 14/23 - EACH
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Nalgene MF75 Receiver 1L - PK12
FIL8026 PK12
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Nalgene CA MF75 1L 0.45um Filter Unit
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FIL8050 PK12
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IKA Impact Grinding Head MF10 2 - EACH
MIL2114 EACH
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Nalgene MF75 Receiver 150ml - PK24
FIL8020 PK24
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Nalgene CA MF75 1L 0.45um Filter Unit - PK12
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Nalgene Nylon MF75 1L 0.2um Filter Unit
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IKA Cutting Grinding Head MF10 1 - EACH
MIL2112 EACH
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Nalgene Nylon MF75 1L 0.2um Filter Unit - PK12
FIL8120 PK12
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Nalgene MF75 PES 90mm x 0.2um x 1L Filter Unit - PK12
FIL8416 PK12
EUR 427.95

Anti-Foxp3 Antibody [MF23], PE-25ug
QAB27-PE-25ug 25ug
EUR 240

Nalgene Nylon MF75 1L 0.45um Filter Unit - PK12
FIL8122 PK12
EUR 473.85

Nalgene PES MF75 90mm x 0.2um x 1L Bottle Top Filter
FIL8195 PK12
EUR 268.8

Nalgene MF75 PES 90mm x 0.45um x 1L Filter Unit - PK12
FIL8418 PK12
EUR 453.6

Anti-Foxp3 Antibody [MF23], APC-25ug
QAB27-APC-25ug 25ug
EUR 240

Anti-Foxp3 Antibody [MF23], PE-100ug
QAB27-PE-100ug 100ug
EUR 442.8

Dreschel Head Adjustable Mf27/3/ - EACH
QMF27/3/13 EACH
EUR 83.7

Nalgene CA MF75 50mm x 0.2um x 150ml Bottle Top Filter
FIL8150 PK12
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Nalgene CA MF75 50mm x 0.2um x 500ml Bottle Top Filter
FIL8154 PK12
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Nalgene CA MF75 50mm x 0.2um x 1L Bottle Top Filter - PK12
FIL8158 PK12
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Nalgene MF75 PES 50mm x 0.1um x 150ml filter unit - PK12
FIL8397 PK12
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Nalgene MF75 PES 50mm x 0.2um x 150ml Filter Unit - PK12
FIL8400 PK12
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Nalgene MF75 PES 75mm x 2um x 250ml Filter Unit - PK12
FIL8404 PK12
EUR 202.5

Nalgene MF75 PES 75mm x 0.2um x 500ml Filter Unit - PK12
FIL8408 PK12
EUR 336.15

Nalgene MF75 PES 90mm x 0.2um x 500ml Filter Unit - PK12
FIL8412 PK12
EUR 395.55

Anti-Foxp3 Antibody [MF23], APC-100ug
QAB27-APC-100ug 100ug
EUR 442.8

Nalgene CA MF75 50mm x 0.45um x 1L Bottle Top Filter - PK12
FIL8148 PK12
EUR 349.65

Nalgene CA MF75 50mm x 0.45um x 150ml Bottle Top Filter
FIL8152 PK12
EUR 109.44

Nalgene CA MF75 50mm x 0.45um x 500ml Bottle Top Filter
FIL8156 PK12
EUR 154.56

Nalgene PES MF75 90mm x 0.2um x 1L Bottle Top Filter - PK12
FIL8181 PK12
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Nalgene PES MF75 75mm x 0.2um x 500ml Bottle Top Filter
FIL8184 PK12
EUR 137.28

We will conduct an electronic search of the following databases from their inception to May 2018: MEDLINE; EMBASE; COCHRANE; China National Knowledge Infrastructure (CNKI) (a Chinese database); CiNii and J-STAGE (Japanese databases); and KoreaMed, Korean Medical Database (KMbase), Korean Studies Information Service System (KISS),

National Digital Science Library (NDSL), Korea Institute of Science and Technology Information (KISTI), Oriental Medicine Advanced Searching Integrated System (OASIS). RCTs investigating any type of TEA will be included. The risk of bias in each study will be evaluated using the Cochrane risk of bias tool.

Risk ratios or mean differences with 95% confidence intervals will be used to show the effects of TEA if it will be possible to conduct a meta-analysis. Sensitivity analyses will also be conducted in this study.

Ethical approval is not necessary as this paper does not involve patient data. The review will be published in a peer-reviewed journal or presented in a conference.PROSPERO CRD42019133060.